Effect of oscillating fluid flow stimulation on osteocyte mRNA expression.

  title={Effect of oscillating fluid flow stimulation on osteocyte mRNA expression.},
  author={Jason Li and Emily E Rose and Daniel Eleazar Antonio Franc{\'e}s and Yu Sun and LiDan You},
  journal={Journal of biomechanics},
  volume={45 2},
Structural adaptation of the bone tissue is mediated by loading-induced interstitial fluid flow within the bone microstructure. Within this framework, osteocytes fulfill the central mechanotransductive role in the bone remodeling process. While osteocytes have been demonstrated to be exquisitely sensitive to various forms of fluid flow stimulus in vitro, the effect of different oscillating fluid flow (OFF) parameters on osteocyte activity has yet to be systematically characterized. In this… CONTINUE READING


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Activation of b-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: implications for the study of mechanosensation in bone

  • M. A. Kamel, J. L. Picconi, N. Lara-Castillo, M. L. Johnson
  • Bone
  • 2010
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