Effect of oriented or random PEGylation on bioactivity of a factor VIII inhibitor blocking peptide.

@article{Kopecky2006EffectOO,
  title={Effect of oriented or random PEGylation on bioactivity of a factor VIII inhibitor blocking peptide.},
  author={E Kopecky and Sabine Greinstetter and Ingrid Pabinger and Andrea Buchacher and Juergen Roemisch and Alois Jungbauer},
  journal={Biotechnology and bioengineering},
  year={2006},
  volume={93 4},
  pages={647-55}
}
Peptides as therapeutic substances are efficient agents in the treatment of several diseases. However, they often have to be chemically modified in order to be suited as therapeutic agent. Conjugation to large carrier molecules is often required. A critical step is the identification of available sites for chemical reaction, without influencing bioactivity. Peptide 238/S1 with the sequence NH(2)-PYWKWQYKYD-COOH previously selected from a combinatorial decapeptide library, has the ability to… CONTINUE READING

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