Effect of organic forms of selenium on delta-aminolevulinate dehydratase from liver, kidney, and brain of adult rats.

@article{Barbosa1998EffectOO,
  title={Effect of organic forms of selenium on delta-aminolevulinate dehydratase from liver, kidney, and brain of adult rats.},
  author={N. B. Barbosa and J. Rocha and G. Zeni and T. Emanuelli and M. C. Beque and A. L. Braga},
  journal={Toxicology and applied pharmacology},
  year={1998},
  volume={149 2},
  pages={
          243-53
        }
}
The inhibitory effect of various forms of organic selenium compounds and of diphenyl ditelluride (PhTe)2 on delta-aminolevulinate dehydratase (delta-ALA-D) from liver, kidney, and brain of rats was investigated because it has been reported that organocalcogens catalyze the oxidation of thiols. Diphenyl diselenide (PhSe)2, rho-chloro-diphenyl diselenide (rho ClPhSe)2, propyl-2-2-diphenyl diselenide, and propyl-2-methoxy-2-phenyl selenide inhibited delta-ALA-D and the IC50 ranged from 2 to 32… Expand
Mechanisms of the inhibitory effects of selenium and mercury on the activity of delta-aminolevulinate dehydratase from mouse liver, kidney and brain.
Mercury is known to interact with selenite and when the two are co-administered, one reduces the toxicity of the other. The main goal of this study was to investigate the simultaneous in vitroExpand
Cadmium inhibits delta-aminolevulinate dehydratase from rat lung in vitro: interaction with chelating and antioxidant agents.
TLDR
It is demonstrated that Cd(2+)inhibited delta-ALA-D activity and chelating and antioxidant agents, alone or combined, did not restore the enzyme activity. Expand
Short communication Mechanisms of the inhibitory effects of selenium and mercury on the activity of d-aminolevulinate dehydratase from mouse liver, kidney and brain
Mercury is known to interact with selenite and when the two are co-administered, one reduces the toxicity of the other. The main goal of this study was to investigate the simultaneous in vitroExpand
Profile of nonprotein thiols, lipid peroxidation and delta-aminolevulinate dehydratase activity in mouse kidney and liver in response to acute exposure to mercuric chloride and sodium selenite.
TLDR
Results suggest that selenium abolishes the interaction of Hg(2+) with sulfhydryl groups of protein and nonprotein sources, which is at least in part, the Hg-induced oxidation of renal and hepatic NPSH. Expand
Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves.
  • M. Farina, N. B. Barbosa, +5 authors J. Rocha
  • Chemistry, Medicine
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2002
TLDR
The results suggest that the interaction of (PhSe)2 with mammal delta-ALA-D requires the presence of cysteinyl residues in close proximity, and the formation of seleninic acid as a product of this reaction may increase the toxicity of organic chalcogens such as (Ph Se)2. Expand
Inhibition of hepatic δ-aminolevulinate dehydratase activity induced by mercuric chloride is potentiated by N-acetylcysteine in vitro.
  • R. Brandão, C. W. Nogueira
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
TLDR
The inhibition of hepatic δ-aminolevulinate dehydratase activity induced by HgCl(2) is potentiated by NAC in vitro, and this effect is not related to hepatic lipid peroxidation. Expand
Mechanism of delta-aminolevulinate dehydratase inhibition by phenyl selenoacetylene involves its conversion to diphenyl diselenide.
TLDR
It is proposed that oxygen could be important in the regeneration of diphenyl diselenide leading to a catalytic oxidation of the enzyme and the lower sensitivity of purified enzyme to selenides could be related to the formation of selenols due to the presence of dithiothreitol in the incubation medium. Expand
Organic and inorganic forms of selenium inhibited differently fish (Rhamdia quelen) and rat (Rattus norvergicus albinus) δ-aminolevulinate dehydratase
TLDR
The results suggest a link between selenium-induced anemia signs in fish and the sensitivity of fish δ-ALA-D to Selenium in natural habitats. Expand
Association between diphenyl diselenide and cadmium chloride attenuates the toxicity of both in tissues of mice in vitro.
TLDR
The results demonstrate that the association between CdCl(2) and (PhSe)(2) attenuates the toxicity of both compounds and the possible mechanisms of this protection are due to complex formation between cadmium and selenium and involves the antioxidant activity of (Ph Se)(2). Expand
Delta-aminolevulinate dehydratase inhibition by phenyl selenoacetylene: effect of reaction with hydrogen peroxide.
TLDR
It is suggested that delta-aminolevulinate dehydratase is a potential molecular target for phenyl selenoacetylene, due to the oxidation of enzyme sulfhydryl groups, and that the monooxygenation of this selenocompound, which in vivo could be possibly mediated by flavin-containing monooxigenases, increases its inhibitory effect. Expand
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