Effect of oral therapy with monoisoamyl meso-2,3-dimercaptosuccinate on 203Hg retention in rats

  title={Effect of oral therapy with monoisoamyl meso-2,3-dimercaptosuccinate on 203Hg retention in rats},
  author={K. Kostial and M. Blanu{\vs}a and M. Piasek and M. Jones and P. K. Singh},
  journal={Bulletin of Environmental Contamination and Toxicology},
4 Citations
Haematological, hepatic and renal alterations after repeated oral or intraperitoneal administration of monoisoamyl DMSA. I. Changes in male rats
This study investigated the dose‐dependent effect of MiADMSA on various biochemical parameters suggestive of alterations in haem biosynthesis and hepatic, renal and brain oxidative stress after 21 days of repeated intraperitoneal (i.p.) or oral (p.o.) administration to rats. Expand
Assessment of the protective activity of monisoamyl meso-2,3-dimercaptosuccinate against methylmercury-induced maternal and embryo/fetal toxicity in mice.
The intrinsic toxicity of Mi-ADMS would be a restrictive factor for the possible therapeutic use of this chelator in pregnant women exposed to organic mercury. Expand
Monoisoamyl and mono‐n‐hexyl meso‐2,3‐dimercaptosuccinate in mobilizing 203hg retention in relation to age of rats and route of administration
Monoisoamyl (Mi‐ADMS) and mono‐n‐hexyl (Mn‐HDMS) monoesters of meso‐2,3‐dimercaptosuccinic acid (DMSA) were given orally or parenterally for the mobilization of inorganic mercury in suckling andExpand
Reduction of lead retention by mono-3-methylbutan-1-yl meso-2,3-dimercaptosuccinate in suckling rats.
The major finding is that Mi-ADMS at low doses causes a much higher reduction in brain retention of lead in sucklings than DMSA, important because the brain is considered to be the target organ of lead toxicity in the youngest age group. Expand


Decreasing 203Hg retention by intraperitoneal treatment with monoalkyl esters of meso‐2,3‐dimercaptosuccinic acid in rats
The effect of nine monoalkyl esters of meso‐2,3‐dimercaptosuccinic acid (DMSA) on 203Hg retention after a single i.p. dose was evaluated in 6–7 week‐old female albino rats, with a significantly lower body burden of mercury than the controls. Expand
Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse.
The monoisoamyl ester was the most effective in removing cadmium from both the liver and the kidneys when given orally and is the first compound which is reported capable of mobilizing Cadmium in vivo from aged deposits after oral administration. Expand
Mobilization of lead in mice by administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid.
It is suggested that the ability of these monoesters to cross cell membranes may account for their superiority to DMSA in mobilizing brain lead in this animal model. Expand
New developments in therapeutic chelating agents as antidotes for metal poisoning.
  • M. Jones
  • Chemistry, Medicine
  • Critical reviews in toxicology
  • 1991
An examination of the studies on therapeutic chelating agents that have been carried out during the last decade reveals that extensive efforts have been made to develop compounds superior to thoseExpand
meso-2,3-Dimercaptosuccinic acid: chemical, pharmacological and toxicological properties of an orally effective metal chelating agent.
The primary purpose of this article is to summarize the recent investigations dealing with the pharmacology and toxicology of meso-2,3-dimercaptosuccinic acid, an orally effective chelating agent.Expand
Role of 2,3-Dimercaptosuccinic Acid in the Treatment of Heavy Metal Poisoning
The purpose of this paper is to discuss the development of a recently rediscovered pharmacological agent which has broad clinical implications and numerous pre-clinical studies indicate that dimercaptosuccinic acid should offer a safe and effective means of treating other heavy metal poisonings. Expand