Effect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimus.

@article{SansoneParsons2007EffectOO,
  title={Effect of oral posaconazole on the pharmacokinetics of cyclosporine and tacrolimus.},
  author={Angela Sansone-Parsons and Gopal Krishna and Monika Martinho and Bhavna S Kantesaria and Steven P Gelone and Tim G Mant},
  journal={Pharmacotherapy},
  year={2007},
  volume={27 6},
  pages={825-34}
}
STUDY OBJECTIVE To analyze the pharmacokinetic properties of the immunosuppressants cyclosporine and tacrolimus when either is coadministered with oral posaconazole. DESIGN Two single-center, open-label pharmacokinetic studies of cyclosporine in a multiple-dose design and of tacrolimus in a one-sequence, crossover, single- and multiple-dose design. SETTING One clinical investigative center in the United States and one in the United Kingdom. SUBJECTS Four adult heart transplant recipients… CONTINUE READING

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