Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics

@article{Stoehr1984EffectOO,
  title={Effect of oral contraceptives on triazolam, temazepam, alprazolam, and lorazepam kinetics},
  author={Gary P. Stoehr and Patricia D. Kroboth and Randy P. Juhl and Donald B. Wender and J. Paul Phillips and Randall B. Smith},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1984},
  volume={36}
}
The effects of low‐dose estrogen oral contraceptives (OC) on the elimination of the oxidized benzodiazepines triazolam (TRZ) and alprazolam (ALP) and the conjugated benzodiazepines temazepam (TMZ) and lorazepam (LOR) were studied in two parallel crossover studies of 20 women each. Women taking OC steroids containing low doses of estrogen and women matched for age, weight, and cigarette smoking received single oral doses of TRZ (0.5 mg) and TMZ (30 mg) or ALP (1 mg) and LOR (2 mg). Kinetics were… 
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96 Citations

Pharmacodynamic evaluation of the benzodiazepine–oral contraceptive interaction
TLDR
The data suggest that differences in benzodiazepine pharmacokinetics between OC users and control women do not account for observed differences in psychomotor impairment, and women taking OCs are more sensitive to the Psychomotor effects of single oral doses of Benzodiazepines.
DISPOSITION ral contraceptives containing ethinyl estradiol nd gestodene markedly increase plasma oncentrations and effects of tizanidine by nhibiting cytochrome P 450 1 A 2
TLDR
OCs containing ethinyl estradiol and gestodene increase, to a clinically significant extent, the plasma concentrations and effects of tizanidine, probably mainly by inhibiting its CYP1A2-mediated presystemic metabolism.
Effect of oral contraceptive steroids on the pharmacokinetics of phenprocoumon.
TLDR
The accelerated glucuronidation of phenprocoumon in OCS users suggests the need for careful monitoring of the anticoagulatory response in these subjects, especially when the OCS are withdrawn.
The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects.
TLDR
Oral contraceptives containing ethinyloestradiol but not those containing only LNG decrease CYP2C19 activity and neither of the OC preparations seemed to have an inhibitory effect on the formation of omeprazole sulphone by CYP3A4.
Alprazolam Pharmacokinetics in Women on Low‐Dose Oral Contraceptives
TLDR
Alprazolam free fraction in plasma was slightly but significantly greater in the oral contraceptive group as opposed to the control group, however, comparison of free clearance between groups revealed no significant difference.
Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1k-hydroxylation
TLDR
It is suggested that, at the doses used, ethinylestradiol and gestodene have a relatively small effect on CYP3A4 activity in vivo, and slightly increased the AUC of oral midazolam.
Lack of effect of oral contraceptive use on the pharmacokinetics of quinine.
The pharmacokinetics of quinine after a single 600 mg oral dose of quinine sulphate were studied in seven female subjects who used oral contraceptives and in seven age-matched female controls who did…
Effect of an oral contraceptive preparation containing ethinylestradiol and gestodene on CYP3A4 activity as measured by midazolam 1'-hydroxylation.
TLDR
It is suggested that, at the doses used, ethinylestradiol and gestodene have a relatively small effect on CYP3A4 activity in vivo, and slightly increased the AUC of oral midazolam.
Oral contraception does not alter single dose saquinavir pharmacokinetics in women.
TLDR
Pharmacokinetic interactions of synthetic sexual steroids with saquinavir are not likely to account for the increased ADR to antiretroviral therapy seen in women.
Pharmacokinetics of oxaprozin in women receiving conjugated estrogen
TLDR
Oxaprozin clearance, accomplished by a combination of oxidation and conjugation, is unimpaired by coadministration of conjugatedEstrogen, and the kinetics of a single 1200 mg oral dose was studied in 22 healthy female volunteers.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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