Effect of oral D-tagatose on liver volume and hepatic glycogen accumulation in healthy male volunteers.

@article{Boesch2001EffectOO,
  title={Effect of oral D-tagatose on liver volume and hepatic glycogen accumulation in healthy male volunteers.},
  author={Chris Boesch and Michael Ith and Bernd Jung and Karin Bruegger and Stephen B. Erban and Ioannis Diamantis and Roland Kreis and Antje Baer},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={2001},
  volume={33 2},
  pages={
          257-67
        }
}
Standard toxicity tests with high levels of D-tagatose showed a reversible enlargement of the liver in Sprague-Dawley rats without increase of liver enzymes. The present study tests the hypotheses that partial substitution of dietary sucrose by D-tagatose for 28 days increases the volume of human liver and the concentration of liver glycogen. Twelve healthy, male volunteers were studied in a double-blind crossover study with ingestion of D-tagatose (3x15 g daily) and placebo (sucrose, 3x15 g… CONTINUE READING

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Acknowledgements We are grateful to A.Vogt and the Clinical Investigation Unit for daily supervision of the volunteers

  • A Bär
  • Regul.Toxicol.Pharmacol.,
  • 1993

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