Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats.

@article{Pietras2002EffectOO,
  title={Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats.},
  author={Thomas A Pietras and Neil E. Rowland},
  journal={European journal of pharmacology},
  year={2002},
  volume={442 3},
  pages={237-9}
}
Feeding induced in rats by cerebroventricular (i.c.v.) injection of orphanin FQ was potently and dose-dependently reversed by peripheral injection of either the opioid antagonist naloxone or the cannabinoid CB(1) receptor antagonist SR 141716[N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophelyl)-4-methyl-3-pyrazole-carboxamine]. The combination of these two agents inhibited food intake in a manner suggestive of additivity or supra-additivity. 

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