Effect of oncogene activating mutations and kinase inhibitors on amino acid metabolism of human isogenic breast cancer cells.

@article{Kim2015EffectOO,
  title={Effect of oncogene activating mutations and kinase inhibitors on amino acid metabolism of human isogenic breast cancer cells.},
  author={Eung-Sam Kim and Animesh Samanta and Hui Shan Cheng and Zhaobing Ding and Weiping Han and Luisella Toschi and Young Tae Chang},
  journal={Molecular bioSystems},
  year={2015},
  volume={11 12},
  pages={3378-86}
}
We investigated the changes in amino acid (AA) metabolism induced in MCF10A, a human mammary epithelial cell line, by the sequential knock-in of K-Ras and PI3K mutant oncogenes. Differentially regulated genes associated to AA pathways were identified on comparing gene expression patterns in the isogenic cell lines. Additionally, we monitored the changes in… CONTINUE READING