Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.

  title={Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.},
  author={S Sadanobu and Makoto Takeuchi and Masakatsu Tezuka},
  journal={The Journal of toxicological sciences},
  volume={23 2},
The protective effects of 1,3-dithia-2-thioxo-cyclopent-4-ene (DT827A),4-phenyl-1,3-dithia-2-thioxo-cyclopent- 4-ene (DT827B) and 4-(4-fluorophenyl)-1,3-dithia-2-thioxo-cyclopent-4-ene (DT827C) on liver injury induced by D-galactosamine plus carbon tetrachloride (D-GalN + CCl4) and that of DT827B on liver injury induced by thioacetamide were studied using male rats. Out of the three DT827 series of compounds, DT827B was more effective on liver injury induced by the combination exposure to D… 
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In vitro tests of 1,3-dithia-2-thioxo-cyclopent-4-ene to evaluate the mechanisms of its hepatoprotective action.
The protective effect of DT827A on a liver injury is due neither to its influence on liver GSH levels nor inhibition of the metabolic activation of CCl4, but a possible mechanism of action for theDT827 series of compounds to indicate an antioxidative effect would be brought about by the role of the compounds as a radical scavenger as well as its reductive effect.
Mutagenicity tests of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene.
The mutagenicity of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene was examined in reverse mutation tests, in the chromosomal aberration test with Chinese hamster ovary cells, and in the micronucleus test using mice bone-marrow, finding the increase in polyploidy probably is due to a toxic effect of the compound.


Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.
A hepatoprotective potential of theDT827 series compounds was suggested under the conditions of these studies, and DT827B was considered to be the most effective.
[Effect of malotilate (diisopropyl 1, 3-dithiol-2-ylidenemalonate) on chronic liver injury caused by carbon tetrachloride].
It is difficult to explain the protective effect of malotilate on the liver injury only by this phenomenon, as changes of biochemical parameters and histopathological findings caused by CCl4 were improved thereafter.
The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis.
Observations contribute to an understanding of the orotate-mediated prevention of the galactosamine-induced liver damage, and of the role of pyrimidine nucleotides in this experimental hepatitis.
Thioacetamide- and carbon tetrachloride-induced liver cirrhosis.
  • H. Dashti, B. Jeppsson, S. Bengmark
  • Medicine, Biology
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes
  • 1989
Oral administration of thioacetamide is a simple and reliable method of inducing experimental liver cirrhosis in the rat and the differences in histological appearances and some biochemical parameters may be caused by the different mechanisms of action of CCl4 and thio acetamide.
Studies on the metabolism of thioacetamide-S35 in the intact rat.
The liver, although it is the only organ showing morphological changes after treatment with TAA, did not concentrate TAA-S35 nor retain S35 to any greater extent than the other tissues.
Experimental hepatitis induced by D-galactosamine.
Estimation of Plasma Phosphatase by Determination of Hydrolysed Phenol with Amino-antipyrine
The conditions under which enzymic hydrolysis is carried out are the same as in the King-Armstrong method, as modified by King (1951), the amino-antipyrine reagent (A.A.P.) being used to estimate the phenol liberated.
Significance of endotoxaemia in experimental "galactosamine-hepatitis" in the rat.
It is concluded that endotoxins contribute significantly to the pathogenesis of "Ga1N-hepatitis" and its clinical symptoms.
Liver Tumors in Rats Fed Thiourea or Thioacetamide.
Thiourea administered orally to albino rats for a prolonged period of time induces liver tumors, without liver cirrhosis, in a large percentage of cases at concentrations which may be below those