Effect of omeprazole on the steady-state pharmacokinetics of voriconazole.

@article{Wood2003EffectOO,
  title={Effect of omeprazole on the steady-state pharmacokinetics of voriconazole.},
  author={Nolan Wood and Keith KC Tan and Lynn Purkins and Gary Layton and Julia C Hamlin and Diane Kleinermans and Don Nichols},
  journal={British journal of clinical pharmacology},
  year={2003},
  volume={56 Suppl 1},
  pages={56-61}
}
AIMS Voriconazole, a novel triazole antifungal agent, is metabolized by the cytochrome P450 isoenzymes CYP2C19, CYP2C9, and to a lesser extent by CYP3A4. Omeprazole, a proton pump inhibitor used widely for the treatment of gastric and duodenal ulcers, is predominantly metabolized by CYP2C19 and CYP3A4. The aim of this study was to determine the effects of omeprazole on the steady-state pharmacokinetics of voriconazole. A secondary objective was to characterize the pharmacokinetic profile of an… CONTINUE READING

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