Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers.

Abstract

The present study shows the effect of omeprazole administration on the pharmacokinetics of a sustained-release preparation of carbamazepine in healthy male volunteers. Multiple dose administration of omeprazole increased the Cmax, AUC0-infinity and elimination half life (t1/2e) of carbamazepine. The results suggest that drug monitoring should be carried out when carbamazepine is coadministered with omeprazole.

Cite this paper

@article{Dixit2001EffectOO, title={Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers.}, author={Rakesh Kumar Dixit and Arjun Chawla and Naveen Kumar and S. K. Garg}, journal={Methods and findings in experimental and clinical pharmacology}, year={2001}, volume={23 1}, pages={37-9} }