Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers

@article{Winston2006EffectOO,
  title={Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers},
  author={Alan Winston and David Back and Carl Fletcher and Lesley Robinson and Jennifer Unsworth and Izabela Tolowinska and Malte Schutz and Anton L. Pozniak and Brian George Gazzard and Marta Boffito},
  journal={AIDS},
  year={2006},
  volume={20},
  pages={1401–1406}
}
Introduction:Recent studies have described reduced absorption of certain protease inhibitors when administered with agents known to increase gastric pH. No clinically significant interactions between saquinavir absorption and gastric pH have previously been shown. We evaluated the effect of omeprazole, a proton-pump-inhibitor, on the pharmacokinetics of the recently developed saquinavir-500 mg formulation co-administered with ritonavir. Methods:Eighteen healthy subjects (n = 6 women and 12 men… 

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...

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