Effect of omeprazole-induced hypergastrinaemia on the proliferation of colonic mucosal epithelial cells in the rat.

@article{Pawlikowski1991EffectOO,
  title={Effect of omeprazole-induced hypergastrinaemia on the proliferation of colonic mucosal epithelial cells in the rat.},
  author={Mary Ann Pawlikowski and E. Wajs and Andrzej Lewiński and Mariusz W. Szkudlinski and I Rybicka and Ewa Sewerynek},
  journal={Experimental and clinical endocrinology},
  year={1991},
  volume={97 1},
  pages={
          50-4
        }
}
  • Mary Ann Pawlikowski, E. Wajs, +3 authors Ewa Sewerynek
  • Published in
    Experimental and clinical…
    1991
  • Medicine
  • In the present study we have investigated the effects of proglumide (PRO) and somatostatin analog (SMS 201-995) on the mitotic activity of colonic mucosa in rats under basal conditions and after omeprazole (OM). The stathmokinetic method was used. Proglumide and OM were administered for 5 days, twice daily, SMS 201-995 on the 5th day of the experiment only, also twice daily. It was found that: 1) OM enhanced the proliferation of colonic mucosa, as well as increased serum gastrin, when compared… CONTINUE READING

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