Effect of omalizumab on angioedema in H1 -antihistamine-resistant chronic spontaneous urticaria patients: results from X-ACT, a randomized controlled trial.

@article{Staubach2016EffectOO,
  title={Effect of omalizumab on angioedema in H1 -antihistamine-resistant chronic spontaneous urticaria patients: results from X-ACT, a randomized controlled trial.},
  author={Petra Staubach and Martin Metz and Nadine Chapman-Rothe and Christian Sieder and Matthias Braeutigam and Janice Canvin and Marcus Maurer},
  journal={Allergy},
  year={2016},
  volume={71 8},
  pages={
          1135-44
        }
}
BACKGROUND Chronic spontaneous urticaria (CSU) severely impacts quality of life (QoL), especially in patients with wheals and angioedema. Omalizumab is approved as add-on therapy for CSU patients; however, its effect on patients who are double-positive for wheals and angioedema has not been systematically studied. OBJECTIVE The primary objective was to evaluate the efficacy of omalizumab vs placebo at week 28 using the Chronic Urticaria Quality of Life (CU-Q2oL) questionnaire. Number of… CONTINUE READING
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