Effect of olvanil on the afferent and efferent function of capsaicin-sensitive C-fibers in guinea pig airways.

@article{Stebbins2003EffectOO,
  title={Effect of olvanil on the afferent and efferent function of capsaicin-sensitive C-fibers in guinea pig airways.},
  author={Karin J Stebbins and Michael Carr and Ernie V Pedapati and James L. Ellis},
  journal={European journal of pharmacology},
  year={2003},
  volume={471 3},
  pages={205-11}
}
The aim of the present study was to examine the ability of the nonpungent vanilloid VR1 receptor agonist, olvanil, to activate the afferent and efferent function of capsaicin-sensitive C-fibers in guinea pig airways. We found that while capsaicin (10 nM-10 microM) and resiniferatoxin (0.1 nM-1.0 microM) evoked a robust contraction of the guinea pig trachea in vitro, olvanil (10 nM-10 microM) was a weak spasmogen. In addition, pretreatment with olvanil caused only a minor reduction of subsequent… CONTINUE READING

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