Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule.

@article{Shigenaga2008EffectOO,
  title={Effect of olmesartan on tissue expression balance between angiotensin II receptor and its inhibitory binding molecule.},
  author={Atsu-ichiro Shigenaga and Kouichi Tamura and Hiromichi Wakui and Shin-ichiro Masuda and Koichi Azuma and Yuko Tsurumi-Ikeya and Motoko Ozawa and Masaki Mogi and Miyuki Matsuda and Kazuaki Uchino and Kazuo Kimura and Masatsugu Horiuchi and Satoshi Umemura},
  journal={Hypertension},
  year={2008},
  volume={52 4},
  pages={672-8}
}
We previously cloned a novel molecule interacting with angiotensin II (Ang II) type 1 receptor protein (ATRAP) and showed it to be an endogenous inhibitor of Ang II type 1 receptor signaling in cardiovascular cells. In this study, we tested a hypothesis that the balance of tissue expression of ATRAP and Ang II type 1 receptor is regulated in a tissue-specific manner during the development of hypertension and related cardiac hypertrophy. Concomitant with blood pressure increase and cardiac… CONTINUE READING
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Expression of ATRAP in adipocytes and negative regulation by beta-adrenergic stimulation of JAK/STAT.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 2008

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