Effect of oligosaccharide chain length, exposed terminal group, and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus influenzae type b capsular antigen unterminally coupled to the diphtheria protein CRM197.

@article{Anderson1989EffectOO,
  title={Effect of oligosaccharide chain length, exposed terminal group, and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus influenzae type b capsular antigen unterminally coupled to the diphtheria protein CRM197.},
  author={Porter W. Anderson and Michael E. Pichichero and E Carol Stein and Susan Porcelli and Robert Betts and David M Connuck and David Nathan Korones and Richard Insel and John M. Zahradnik and Ronald Eby},
  journal={Journal of immunology},
  year={1989},
  volume={142 7},
  pages={
          2464-8
        }
}
Vaccines consisting of oligosaccharide (OS) derived from Haemophilus influenzae type b capsular polysaccharide and conjugated to carrier proteins had been shown capable of eliciting memory-type capsular polysaccharide of H. influenza type b antibody responses in human infants, but the structural variables governing immunogenicity were not defined. Here a series of conjugates were made with the diphtheria protein CRM197 and with uniterminally coupled OS haptens that varied in chain length… CONTINUE READING

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