Effect of oestrogen on Mycobacterium avium complex pulmonary infection in mice.

@article{Tsuyuguchi2001EffectOO,
  title={Effect of oestrogen on Mycobacterium avium complex pulmonary infection in mice.},
  author={Kazunari Tsuyuguchi and Kikuo Suzuki and Hiroyuki Matsumoto and Eisaku Tanaka and Ryoichi Amitani and F. Kuze},
  journal={Clinical and experimental immunology},
  year={2001},
  volume={123 3},
  pages={428-34}
}
The purpose of the present study was to elucidate the role of oestrogen in the pathogenesis of Mycobacterium avium complex (MAC) pulmonary disease, which occurs most frequently in postmenopausal women. The study was carried out in a murine infectious model using ovariectomized DBA/2 female mice. Infection with MAC was established by intratracheal administration of bacilli. In some experiments, ovariectomized mice were treated with exogenous 17 beta-estradiol (E2). The number of bacilli in the… CONTINUE READING
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