Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice

@inproceedings{Wang2012EffectOO,
  title={Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice},
  author={Hui-ting Wang and Chu-feng Liu and Tzu-hsien Tsai and Yung-Lung Chen and H. W. Chang and Ching-Yen Tsai and Steve Leu and Yen-yi Zhen and Han-Tan Chai and S Y Chung and Sarah Chua and Chia-Hung Yen and Hon-Kan Yip},
  booktitle={Journal of Translational Medicine},
  year={2012}
}
Obesity is an important cardiovascular risk factor. This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice. Eight-week-old C57BL/6 J mice (n=24) were equally divided into control (fed a control diet for 22 weeks), obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, 8 weeks). Animals were sacrificed at post 22-week… CONTINUE READING