Effect of obesity on insulin signaling through JAK2 in rat aorta.

  title={Effect of obesity on insulin signaling through JAK2 in rat aorta.},
  author={Henrique Gottardello Zecchin and Claudio Teodoro de Souza and Patr{\'i}cia Oliveira Prada and Jos{\'e} Barreto Campello Carvalheira and Licio Augusto Velloso and Mario Jos{\'e} Abdalla Saad},
  journal={Vascular pharmacology},
  volume={43 5},
Pathway specific resistance to insulin signaling through PI 3-kinase/Akt/eNOS associated with a normal or hyper-activated MAP kinase signaling in vascular tissues has recently been proposed as a candidate link between cardiovascular disease and insulin resistance. Growth stimulatory pathways other than ERK/MAP kinase, such as JAK/STAT have not yet been investigated in vessels of animal models of insulin resistance. Here we have examined whether insulin is able to activate JAK2/STAT pathway in… CONTINUE READING

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