Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects

@article{Salome2008EffectOO,
  title={Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects},
  author={Cheryl M Salome and Phillip A. Mu{\~n}oz and Norbert Berend and C. William Thorpe and Linda M. Schachter and Gregory G. King},
  journal={International Journal of Obesity},
  year={2008},
  volume={32},
  pages={502-509}
}
Background:Obesity is associated with increased prevalence and incidence of asthma, but the mechanism is unknown. Obesity reduces lung volumes, which can increase airway responsiveness, and increases resistive and elastic work of breathing, which can increase dyspnea.Objective:To determine if the intensity of dyspnea due to airway narrowing or if airway responsiveness is increased in obese, non-asthmatic subjects.Subjects:Twenty-three obese (BMI (body mass index) ⩾30 kg m−2) and 26 non-obese… CONTINUE READING

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