Effect of o-benzyl-p-chlorophenol on drug-metabolizing enzymes in rats.

@article{Kao1986EffectOO,
  title={Effect of o-benzyl-p-chlorophenol on drug-metabolizing enzymes in rats.},
  author={L. R. Kao and Joyce A. Goldstein and Linda S Birnbaum},
  journal={Biochemical pharmacology},
  year={1986},
  volume={35 4},
  pages={
          613-20
        }
}
o-Benzyl-p-chlorophenol (BCP) is widely used as a broad spectrum disinfectant. Treatment of male Fischer 344 rats with BCP resulted in an increase in cytochrome P-450 content and an accompanying decrease in aryl hydrocarbon hydroxylase (AHH) activity in both liver and kidney microsomes. Several other drug-metabolizing enzymes were not affected by BCP treatment. However, in kidney, BCP induced NADPH-cytochrome c reductase and uridine diphosphate glucuronyl transferase activities and caused a… CONTINUE READING