Effect of norfloxacin, a new quinolone, on GABA modulation of TRH-induced TSH release from perifused rat pituitaries.

  title={Effect of norfloxacin, a new quinolone, on GABA modulation of TRH-induced TSH release from perifused rat pituitaries.},
  author={J. Roussel and L. Tapia-Arancibia and J. Jourdan and H. Astier},
  journal={Acta endocrinologica},
  volume={119 4},
The effect of the quinolone norfloxacin, a new antibacterial agent that is thought to induce convulsions in patients by inhibiting the binding of GABA, was tested on the two kinds of GABA A modulation of fTRH-induced TSH release from perifused rat pituitaries. Norfloxacin (50 mumol/l) was found to reverse the inhibitory effect of GABA (100 nmol/l) on the TSH release induced by TRH (10 nmol/l). The ratio of induced over spontaneous release was 0.79 +/- 0.05 in the presence of GABA, and 2.32… Expand
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Involvement of inhibitory and excitatory neurotransmitters in levofloxacin- and ciprofloxacin-induced convulsions in mice.
It is suggested that LVFX has fewer effects on the brains than CPFX and that convulsions induced by these quinolones alone and by thesequinolones administered with BPAA may be mediated largely through glutamate and GABA(B) rather than GABA(A) receptors in mice. Expand
Effects of quinolone carboxylic acid derivatives on GABAA receptor-mediated stimulation of gastric acid secretion and intestinal motility.
Results suggest that the quinolone derivatives tested act as antagonists at both central and peripheral GABAA receptors, and might represent a simple and reliable method to assay the GabAA receptor antagonist properties of new quinolinone derivatives. Expand
Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats.
The results suggest that EL rats may be a useful model for humans and that the convulsant effect of LVFX with or without BPAA arises not only from the attainment of maximum brain concentration but also from delayed disappearance from the brain. Expand
GABAA Receptor Mediated Elevation of Ca2+ and Modulation of Gonadotrophin‐Releasing Hormone Action in αT3‐1 Gonadotropes
These data provide the first direct evidence for expression of excitatory GABAA receptors, and the first demonstration of acute steroid effects, on GnRH‐responsive pituitary cells, and reveal a novel mechanism by which GAB AA activation modulates GnRH action, raising the possibility that this may also influence gonadotrophin secretion from non‐immortalized gonadotropes. Expand
Epithelial localization of green fluorescent protein-positive cells in epididymis of the GAD67-GFP knock-in mouse.
The data suggest that the GABA system might have important functional roles in narrow cells and on spermatozoa in the lumen. Expand