Effect of norbinaltorphimine on ∆9-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats

@article{Flax2015EffectON,
  title={Effect of norbinaltorphimine on ∆9-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats},
  author={Shaun M. Flax and Alison G. P. Wakeford and Kejun Cheng and Kenner C. Rice and Anthony L. Riley},
  journal={Psychopharmacology},
  year={2015},
  volume={232},
  pages={3193-3201}
}
The aversive effects of ∆9-tetrahydrocannabinol (THC) are mediated by activity at the kappa opioid receptor (KOR) as assessed in adult animals; however, no studies have assessed KOR involvement in the aversive effects of THC in adolescents. Given that adolescents have been reported to be insensitive to the aversive effects induced by KOR agonists, a different mechanism might mediate the aversive effects of THC in this age group. The present study was designed to assess the impact of KOR… CONTINUE READING
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