Effect of nonsedative doses of propofol on an innate anxiogenic situation in rats.

@article{Pain1999EffectON,
  title={Effect of nonsedative doses of propofol on an innate anxiogenic situation in rats.},
  author={Laure Pain and Philippe Oberling and Anne Launoy and Georges Di Scala},
  journal={Anesthesiology},
  year={1999},
  volume={90 1},
  pages={191-6}
}
BACKGROUND The effect of propofol on anxiety has not been well studied. In humans, such investigations are confused by the fact that sedation often coexists with anxiolysis. Therefore, the authors evaluated the effects of minimal sedation with propofol in rats placed in an innate anxiogenic situation, the elevated plus-shaped maze. METHODS In experiment 1, spontaneous locomotor activity was determined in rats as a measure of sedative effect induced by propofol (0-9 mg/kg administered… CONTINUE READING

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