Effect of non-insulin dependent diabetes on cyclosporin A disposition in Goto-Kakizaki (GK) rats.

@article{Ogata1997EffectON,
  title={Effect of non-insulin dependent diabetes on cyclosporin A disposition in Goto-Kakizaki (GK) rats.},
  author={Masahiro Ogata and Tatsuo Uchimura and Yukisumi Iizuka and Ryoichi Murata and Sachi Suzuki and Takayoshi Toyota and Nobuyuki Hikichi},
  journal={Biological & pharmaceutical bulletin},
  year={1997},
  volume={20 9},
  pages={1026-9}
}
We previously reported that the pharmacokinetics of cyclosporin A (CyA), particularly absorption, were altered in diabetic rats treated with streptozotocin. In the present study, the effect of diabetes on pharmacokinetics of CyA after intravenous and oral administration of CyA using the blood and lymph and the gastrointestinal transit were examined in Goto-Kakizaki (GK) rats, a genetic model of non-obese non-insulin-dependent diabetes mellitus (NIDDM), and compared to non-diabetic Wistar rats… CONTINUE READING