Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function.

@article{Myles2008EffectON,
  title={Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function.},
  author={Paul S. Myles and Matthew T. V. Chan and David M Kaye and David R. McIlroy and Chung-Wai Lau and Joel Ari Symons and Shaohui Chen},
  journal={Anesthesiology},
  year={2008},
  volume={109 4},
  pages={
          657-63
        }
}
BACKGROUND Endothelial function is impaired with hyperhomocysteinemia. Plasma homocysteine is increased by nitrous oxide anesthesia. The current study was designed to determine whether endothelial function is impaired after surgery and whether this is made worse by exposure to nitrous oxide. METHODS The authors studied 59 patients with cardiovascular disease undergoing noncardiac surgery. Patients were randomly allocated to nitrous oxide-based anesthesia (n = 25) or nitrous oxide-free… CONTINUE READING

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