Effect of nitrofurans antagonistic to 3'-methyl-4-dimethylaminoazobenzene in hepatocarcinogenesis and RNA polymerase activity of liver cell nuclei in rats.


RNA polymerase activity of liver nuclei; and (c) whether the nitrofurans ameliorated 3'-Me-DAB-induced changes in RNA polymerase activity. The nitrofurans were 2-(2furyl)-3-(5-nitro-2-furyl)acrylamide and 2-amino-5-[2-(5nitro-2-furyl)-l-(2-furyl)vinyl-l-]-l ,3,4-oxadiazole. Male Donryu rats were fed 1 or 0.5 g of 3'-Me-DAB by being maintained on a diet… (More)

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