Effect of nitrofuran preparations on spermatogenesis


The effect of n i t rofurantoin and furagin on spe rma togenes i s was studied in exper iments on ma le albino r a t s . The p r epa ra t i ons studied were found to have a speci f ic gonadotoxic action. The p r o c e s s e s main ly af fec ted were spe rmiogenes i s and the late s tages of the cycle of the spe rma togen ic epi thel ium. These d is turbances were accompanied by a dec r ea se in the nucleic acid content in the ce l l s , espec ia l ly in the s e r i e s of s p e r m a t o c y t e s and spe rma t id s . The re was a pa ra l l e l d e c r e a s e in the concentra t ion of spe rma tozoa and in the durat ion of the i r mot i l i ty . Recovery f rom these d is turbances took place only a f t e r a complete per iod of spe rma togenes i s although the number of tubules with desquamated spe rmatogen ic ep i thelium continued to be inc reased .

DOI: 10.1007/BF00797415

1 Figure or Table


Citations per Year

332 Citations

Semantic Scholar estimates that this publication has 332 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Yunda1974EffectON, title={Effect of nitrofuran preparations on spermatogenesis}, author={I. F. Yunda and Yu. I. Kushniruk}, journal={Bulletin of Experimental Biology and Medicine}, year={1974}, volume={77}, pages={534-536} }