Effect of nitric oxide synthase inhibition on the cerebral vascular response to hypercapnia in primates.

@article{MCPHERSON1995EffectON,
  title={Effect of nitric oxide synthase inhibition on the cerebral vascular response to hypercapnia in primates.},
  author={ROBERT W. MCPHERSON and Jeffrey R. Kirsch and Ramsis F. Ghaly and Richard J. Traystman},
  journal={Stroke},
  year={1995},
  volume={26 4},
  pages={682-7}
}
BACKGROUND AND PURPOSE The role of nitric oxide in cerebrovascular response to changes in PCO2 is unclear. In the present study, we assessed responses at two levels of hypercapnia in a primate model before and after blockade of nitric oxide synthesis. METHODS We compared the effects of two levels of hypercapnia, defined as PCO2 of approximately 70 mm Hg (high-CO2 group, n = 5) and PCO2 of approximately 50 mm Hg (moderate-CO2 group, n = 6), on increases in regional cerebral blood flow… CONTINUE READING

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