Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study.

@article{Dzavk2007EffectON,
  title={Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study.},
  author={Vladim{\'i}r Dz̆av{\'i}k and Gad Cotter and Harmony R. Reynolds and John Hunter Alexander and Krishnan Ramanathan and Amanda L Stebbins and David R. Hathaway and Michael E. Farkouh and E Magnus Ohman and David A Baran and Roland Prondzinsky and Julio A. Panza and Warren J. Cantor and Zvi Vered and Christopher E H Buller and Neal S. Kleiman and John G Webb and David R. Holmes and Joseph E. Parrillo and Stanley L. Hazen and Steven S. Gross and Robert A. Harrington and Judith S. Hochman},
  journal={European heart journal},
  year={2007},
  volume={28 9},
  pages={
          1109-16
        }
}
AIMS Previous studies suggested haemodynamic benefits and, possibly, mortality reduction with the use of nitric oxide synthase (NOS) inhibition in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). We assessed preliminary efficacy and safety of four doses of l-n-monomethyl-arginine (l-NMMA), a non-selective NOS inhibitor, in patients with AMI complicated by CS despite an open infarct-related artery. METHODS AND RESULTS Patients (n = 79) were randomly… CONTINUE READING

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