Effect of nicotine on the pharmacokinetics of levodopa.

Abstract

OBJECTIVES Some patients with Parkinson disease improved their symptoms on treatment with nicotine patch or gum. Nicotine has also been studied for its antidyskinetic effect on levodopa-induced dyskinesia. We determined the effects of nicotine on levodopa pharmacokinetics and gastric emptying in healthy subjects and on levodopa transport in Caco-2… (More)
DOI: 10.1097/WNF.0b013e31827fd9cd

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