[Effect of nicotine on insulin secretion in the isolated perfused rat pancreas].

Abstract

Insulin secretion induced by glucose (1.5 g/l) is changed by nicotine infusion; the recorded changes depend on the nicotine concentration uses. 1) At a low concentration (0.05 mM) nicotine provokes an immediate, progressively increasing and lasting stimulation of insulin secretion. This stimulation is inhibited by hexamethonium (0.1 mM) and atropine (0.3 micrometer). 2) At a high concentration (1 mM) nicotine has a triphasic effect on insulin secretion : brief decrease, peak of stimulation and prolonged decrease. Hexamethonium decreases the stimulation and suppresses the prolonged inhibition.

Cite this paper

@article{Chapal1978EffectON, title={[Effect of nicotine on insulin secretion in the isolated perfused rat pancreas].}, author={Jeannie Chapal and Marie-Madeleine Loubati{\`e}res-Mariani}, journal={Comptes rendus des séances de la Société de biologie et de ses filiales}, year={1978}, volume={172 1}, pages={156-60} }