Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

@inproceedings{Long2015EffectON,
  title={Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model},
  author={Aaron N Long and Katrina L Owens and Anna Elise Schlappal and Tibor Kristian and Paul S. Fishman and Rosemary A. Schuh},
  booktitle={BMC neurology},
  year={2015}
}
BACKGROUND Mitochondrial dysfunction is a hallmark of neurodegenerative diseases including Alzheimer's disease (AD), with morphological and functional abnormalities limiting the electron transport chain and ATP production. A contributing factor of mitochondrial abnormalities is loss of nicotinamide adenine dinucleotide (NAD), an important cofactor in multiple metabolic reactions. Depletion of mitochondrial and consequently cellular NAD(H) levels by activated NAD glycohydrolases then culminates… CONTINUE READING