Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells

@inproceedings{PrulireEscabasse2010EffectON,
  title={Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells},
  author={Virginie Pruli{\`e}re-Escabasse and Christine Cl{\'e}rici and Gr{\'e}goire Vuagniaux and Andr{\'e} Coste and Estelle Escudier and Carole Plan{\`e}s},
  booktitle={Respiratory research},
  year={2010}
}
BACKGROUND Hyperactivity of the epithelial sodium (Na+) channel (ENaC) and increased Na+ absorption by airway epithelial cells leading to airway surface liquid dehydration and impaired mucociliary clearance are thought to play an important role in the pathogenesis of cystic fibrosis (CF) pulmonary disease. In airway epithelial cells, ENaC is constitutively activated by endogenous trypsin-like serine proteases such as Channel-Activating Proteases (CAPs). It was recently reported that ENaC… CONTINUE READING

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