Effect of neuroserpin in a neonatal hypoxic-ischemic injury model ex vivo.

@article{Ma2012EffectON,
  title={Effect of neuroserpin in a neonatal hypoxic-ischemic injury model ex vivo.},
  author={Jiao Ma and Dan Yu and Yu Neng Tong and M. Castro Mao},
  journal={Biological research},
  year={2012},
  volume={45 4},
  pages={
          357-62
        }
}
Hypoxia-ischemia (HI) occurring in immature brains stimulates the expression of tissue-type plasminogen activator (tPA). Neuroserpin is a selected inhibitor of tPA in the central nerves system. However, the role that neuroserpin plays and the possible mechanisms involved during neonatal HI are poorly defined. In this study, an oxygen-glucose deprivation and reoxygenation (OGD/R) model was generated with cultured rat cortical neurons mimicking neonatal HI injury ex vivo, and an acute neuronal… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 34 REFERENCES

Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia.

  • The American journal of pathology
  • 2008
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2009
VIEW 3 EXCERPTS

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