Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog.

@article{Inoue1989EffectON,
  title={Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog.},
  author={T. Inoue and Akio Inui and M. Okita and Noriaki Sakatani and M. Oya and Hiroshi Morioka and N. Mizuno and Munetada Oimomi and Shigeaki Baba},
  journal={Life sciences},
  year={1989},
  volume={44 15},
  pages={
          1043-51
        }
}
There is increasing evidence that neuropeptide Y (NPY) affects the release of pituitary hormones, including adrenocorticotropic hormone (ACTH). The present study was designed to clarify the mechanism by which NPY activates the hypothalamic-pituitary-adrenal (HPA) axis in the dog. Mongrel dogs were equipped with a chronic cannula allowing intra-third (i.t.v.) or intra-lateral (i.l.v.) cerebroventricular administration. A 1.19 nmol, i.t.v. dose of NPY produced as great an ACTH and cortisol… Expand
Structural requirements for the effects of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog
TLDR
It is demonstrated that the entire NPY molecule is required for the full expression of the stimulatory effect of NPY on the secretion of ACTH and cortisol. Expand
Brain neuropeptide Y in the control of adrenocorticotropic hormone secretion in the dog
TLDR
Investigation of the role of endogenous neuropeptide Y in the adrenocorticotropic hormone release after hypoglycemic stress in the dog suggests involvement by endogenous NPY in the ACTH secretion induced by hypoglycemia. Expand
Neuropeptide Y (NPY) actions on the corticotroph cell of the anterior pituitary gland are not mediated by a direct effect
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NPY induced activation of the HPA axis is likely to be mediated via a modulation of hypothalamic CRH and not via a direct action at the level of the anterior pituitary. Expand
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TLDR
These observations provide the first evidence that selective stimulation of Y(5) receptor provokes activation of the HPA axis and its downstream pathway is chiefly composed of both CRF (primary regulator) and AVP (subordinate to the former) with distinct relative contribution. Expand
Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus.
TLDR
Central administration of NPY increases the CRF mRNA levels in the hypothalamus and the probable CRF release, which increases the proopiomelanocortin mRNA levels and ACTH secretion in the anterior pituitary, indicating that NPY seems to play a physiological role in the regulation of the release and synthesis of CRF in theothalamus. Expand
Peptide analogue studies of the hypothalamic neuropeptide Y receptor mediating pituitary adrenocorticotrophic hormone release.
  • C. Small, D. Morgan, +12 authors S. Bloom
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
TLDR
The hypothalamic NPY receptor mediating increases in plasma ACTH has a fragment activation profile unlike the Y1-Y4 or Y6 receptors and appears distinct from theNPY receptor controlling food intake. Expand
Effect of centrally administered neuropeptide Y on hypothalamic and hypophyseal proopiomelanocortin-derived peptides in the rat
TLDR
Quantitative in situ hybridization histochemistry showed that chronic administration of neuropeptide Y caused a reduction of proopiomelanocortin messenger RNA levels both in the intermediate and anterior lobes of the pituitary. Expand
Neuropeptide‐Y Stimulates Pituitary‐Adrenal Activity in Fetal and Adult Sheep
TLDR
The simultaneous addition of NPY did not alter the ability of cortisol to inhibit CRF‐stimulated ACTH secretion and had no effect on basal ACTH release. Expand
Further investigations on the effects of neuropeptide Y on the secretion and growth of rat adrenal zona glomerulosa
TLDR
NPY is able to stimulate not only the secretion, but also the growth of adrenal ZG in rats, via a receptor-mediated mechanism (since this effect is blocked by PYX-2), and may play a crucial role in the fine tuning of the ZG functions in conditions requiring an increased release of mineralocorticoid hormones. Expand
Neuropeptide regulation of hormone secretion from the anterior pituitary gland of the ewe
TLDR
It is suggested that the intrinsic communication between L HRH neurones may be inhibitory and may provide a mechanism to affect the timing of the pulsatile release of LHRH. Expand
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TLDR
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TLDR
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