Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog.

@article{Inoue1989EffectON,
  title={Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog.},
  author={Tomoyuki Inoue and Akio Inui and Motoichi Okita and Norimitsu Sakatani and Michihiro Oya and Hiroshi Morioka and Nobuhiro Mizuno and Munetada Oimomi and Shigeaki Baba},
  journal={Life sciences},
  year={1989},
  volume={44 15},
  pages={
          1043-51
        }
}
There is increasing evidence that neuropeptide Y (NPY) affects the release of pituitary hormones, including adrenocorticotropic hormone (ACTH). The present study was designed to clarify the mechanism by which NPY activates the hypothalamic-pituitary-adrenal (HPA) axis in the dog. Mongrel dogs were equipped with a chronic cannula allowing intra-third (i.t.v.) or intra-lateral (i.l.v.) cerebroventricular administration. A 1.19 nmol, i.t.v. dose of NPY produced as great an ACTH and cortisol… CONTINUE READING
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