Effect of neuroleptics on acetylcholine metabolism in the basal ganglia

Abstract

Neuroleptics (haloperidol, clozapine, pimozide, chlorpromazine) caused a decrease in the level of the free (functionally active) form of acetylcholine (ACh) and also, to some extent, of the bound form of ACh, inconsistent changes in the content of loosely bound (vesicular) form of ACh, and a weak effect on choline acetyltransferase activity in the basal… (More)
DOI: 10.1007/BF00801984

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