Effect of neurohumoral modulators on the morphine-induced hyperthermia in non-tolerant rats.

  title={Effect of neurohumoral modulators on the morphine-induced hyperthermia in non-tolerant rats.},
  author={Tetsuo Oka and Kazuko Negishi},
  journal={European journal of pharmacology},
  volume={42 3},
  • T. Oka, K. Negishi
  • Published 1977
  • Chemistry, Medicine
  • European journal of pharmacology
Wistar rats from one supplier have been shown to exhibit the atypical body temperature responses to morphine. In contrast to commonly used rats, in which morphine induced dose-dependent changes in body temperature, the initial administration of morphine (5, 10, 20, and 40 mg/kg, s.c.) to rats of this particular strain produced a consistent and prominent hyperthermia. This hyperthermia is mediated via an action on the typical morphine receptors since it was completely prevented by a specific… Expand
Morphine hyperthermia in rats: role of neurochemical substances in brain.
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Influence of opioids on central thermoregulatory mechanisms
  • W. G. Clark
  • Medicine
  • Pharmacology Biochemistry and Behavior
  • 1979
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Opiates and opioids have long been known to produce changes in body temperature. As with a wide variety of drugs from many different classes of pharmacological agents, the specific effect on bodyExpand
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