Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils.

@article{Bischoff1992EffectON,
  title={Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils.},
  author={Stephan C. Bischoff and Clemens Andreas Dahinden},
  journal={Blood},
  year={1992},
  volume={79 10},
  pages={2662-9}
}
Nerve growth factor (NGF) is a neurotrophic cytokine known to regulate the survival and function of peripheral and central neuronal cells. Recently, the spectrum of action could be extended to non-neuronal cell types such as rat mast cells and human B lymphocytes. The present study shows that NGF affects the function of mature human basophils isolated from the peripheral blood of healthy donors. Both murine NGF 7S and recombinant human NGF beta enhance histamine release and strongly modulate… CONTINUE READING

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