Effect of neonatal or later capsaicin treatment on bronchial reactivity in sensitized rats. Relation to humoral changes.

@article{Nilsson1989EffectON,
  title={Effect of neonatal or later capsaicin treatment on bronchial reactivity in sensitized rats. Relation to humoral changes.},
  author={Gunnar P Nilsson and Kjell Alving and Jan M. Lundberg and Staffan Ahlstedt},
  journal={International archives of allergy and applied immunology},
  year={1989},
  volume={88 1-2},
  pages={
          234-6
        }
}
Treatment of ovalbumin-sensitized rats with capsaicin resulted in altered bronchial reactivity to both ovalbumin and serotonin. The increase in bronchial reactivity to ovalbumin in neonatally capsaicin-treated rats compared to animals only sensitized may be influenced by the changed ratios of IgA, IgE, and IgG antibodies, together with the inflammation in the lung. Thus, capsaicin given neonatally inhibited the formation of antibodies, both specific titers and total levels, in bronchial lavage. 

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Sensory neuropeptides may not be important in allergen induced acute airway microvascular leakage in guinea pig in vivo.

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