Effect of neonatal isolation on outcome following neonatal seizures in rats--the role of corticosterone.

@article{Lai2006EffectON,
  title={Effect of neonatal isolation on outcome following neonatal seizures in rats--the role of corticosterone.},
  author={Ming-Chi Lai and Gregory L. Holmes and Ko-Hung Lee and San-Nan Yang and Chien-An Wang and C Wu and M M Tiao and Chih-Sung Hsieh and Chiang-Hsuan Lee and Li-Tung Huang},
  journal={Epilepsy research},
  year={2006},
  volume={68 2},
  pages={123-36}
}
Emerging evidence indicates that early maternal care permanently modifies the activity of hypothalamic-pituitary-adrenal (HPA) axis and is a critical factor in determining the capacity of the brain to compensate for later encountered insults. The purpose of this study was to determine the role of corticosterone (CORT) in the detrimental effects of neonatal isolation (NI) on seizures. Rats were assigned randomly to the following five groups: (1) control (CONT) rats; (2) NI rats that underwent… CONTINUE READING
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