Effect of negative pressure ventilation in severe chronic obstructive pulmonary disease

@article{Shapiro1992EffectON,
  title={Effect of negative pressure ventilation in severe chronic obstructive pulmonary disease},
  author={Stan Shapiro and Pierre Ernst and Katherine Gray-Donald and James Martin and Sharon Wood-Dauphinee and A Beaupr{\'e} and Walter O. Spitzer and Peter T. Macklem},
  journal={The Lancet},
  year={1992},
  volume={340},
  pages={1425-1429}
}
The hypothesis that patients with chronic obstructive pulmonary disease (COPD) have chronic inspiratory muscle fatigue was tested in an effectiveness trial in which negative pressure ventilation (NPV) was used to produce inspiratory muscle rest. In a double-blind study 184 patients with severe COPD were randomly allocated active or sham NPV treatment for a 12-week period of home use. The distance walked in a 6 min walk test was the primary outcome variable. Secondary outcome measures were cycle… CONTINUE READING

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