Effect of nedocromil sodium on down-regulation of pulmonary beta-adrenoceptors.

Abstract

1. We have studied the effect of the anti-inflammatory anti-asthma drug, nedocromil sodium, on down-regulation of pulmonary beta-adrenoceptors in guinea-pig lung. 2. Incubation of minced lung with isoprenaline (10 mumol/l) resulted in a reduction in maximum binding capacity of [125I]iodocyanopindolol to lung membranes from 246 +/- 4 to 169 +/- 6 fmol/mg of… (More)

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@article{Kioumis1989EffectON, title={Effect of nedocromil sodium on down-regulation of pulmonary beta-adrenoceptors.}, author={Ioannis P. Kioumis and Dieter Ukena and P. J. Barnes}, journal={Clinical science}, year={1989}, volume={76 6}, pages={599-602} }