Effect of nebracetam on the disruption of spatial cognition in rats.

@article{Iwasaki1992EffectON,
  title={Effect of nebracetam on the disruption of spatial cognition in rats.},
  author={Kiyo Iwasaki and Yoshiaki Matsumoto and Michihiro Fujiwara},
  journal={Japanese journal of pharmacology},
  year={1992},
  volume={58 2},
  pages={
          117-26
        }
}
Central cholinergic hypofunction causes the disruption of spatial cognition, while cholinomimetics improve this disruption in rats. Scopolamine (0.5 mg/kg, i.p.) has also been reported to disrupt radial maze performance in rats. Nebracetam (WEB 1881 FU), a new nootropic candidate, was able to correct this scopolamine-induced disruption of spatial cognition at the dose of 10 mg/kg, p.o. Furthermore, nebracetam enhanced oxotremorine-induced tremors in mice. These results indicate that nebracetam… 

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References

SHOWING 1-10 OF 33 REFERENCES

Scopolamine amnesia of passive avoidance: a deficit of information acquisition.

  • D. Rush
  • Biology, Psychology
    Behavioral and neural biology
  • 1988

Pharmacology of WEB 1881-FU, a central cholinergic agent, which enhances cognition and cerebral metabolism.

TLDR
From the results, it is believed that the stimulating effect of WEB 1881 FU upon the central cholinergic system is modulatory rather than direct, and the combination of nootropic and cholinomimetic properties appears favorable for treatment of brain dysfunction in the elderly.

Effects of WEB 1881 FU, a novel nootropic, on cholinergic and adrenergic receptors in the rat brain: action on M1-muscarinic receptors.

TLDR
4-aminomethyl-1-benzylpyrrolidin-2-one-hemifumarate seems to act on M1-mACh receptors, and its long-term administration probably induces the down-regulation of mACh receptors in the hippocampus and striatum and M2-mA choline receptor in the cerebellum.

Berry CA: Effect of cholinergic drugs on passive avoidance in the mouse.

  • S. L. Dilts
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1967
TLDR
Negative results obtained with corresponding quaternary drug derivatives indicate that the peripheral effects of the drugs examined do not contribute materially to the test results.

Differences in cholinergic agonist- and cholinergic antagonist-induced changes in avoidance responses between dd mice and Wistar rats.

  • H. KuribaraS. Tadokoro
  • Biology, Psychology
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology
  • 1983
TLDR
The results suggest that the neural activities of the central muscarinic-cholinergic systems are different between dd mice and Wistar rats.