Effect of nebracetam on the disruption of spatial cognition in rats.

@article{Iwasaki1992EffectON,
  title={Effect of nebracetam on the disruption of spatial cognition in rats.},
  author={K. Iwasaki and Y. Matsumoto and M. Fujiwara},
  journal={Japanese journal of pharmacology},
  year={1992},
  volume={58 2},
  pages={
          117-26
        }
}
Central cholinergic hypofunction causes the disruption of spatial cognition, while cholinomimetics improve this disruption in rats. Scopolamine (0.5 mg/kg, i.p.) has also been reported to disrupt radial maze performance in rats. Nebracetam (WEB 1881 FU), a new nootropic candidate, was able to correct this scopolamine-induced disruption of spatial cognition at the dose of 10 mg/kg, p.o. Furthermore, nebracetam enhanced oxotremorine-induced tremors in mice. These results indicate that nebracetam… Expand
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