Effect of nebivolol on cardiovascular changes associated with a rat model of insulin-resistance.

@article{Renna2005EffectON,
  title={Effect of nebivolol on cardiovascular changes associated with a rat model of insulin-resistance.},
  author={Nicol{\'a}s Federico Renna and Norma R. Risler and Montserrat C. Cruzado and Susana Gonz{\'a}lez and Carmen M Lama and Roberto Miguel Miatello},
  journal={Cellular and molecular biology},
  year={2005},
  volume={51 6},
  pages={531-7}
}
Nebivolol is a vasodilator that combines beta-adrenergic blocking activity with a relaxant effect on vascular smooth muscle cells (VSMC) mediated by the endothelial nitric oxide (NO) pathway. FFR provide a model of dietary-induced insulin-resistance syndrome, which has been used to study the pathophysiological mechanisms associated with this syndrome. Our main objective was to examine the effect of long-term administration of nebivolol on metabolic and cardiovascular variables in fructose-fed… CONTINUE READING
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