Effect of naringin on ammonium chloride-induced hyperammonemic rats: A dose-dependent study

@article{Arumugam2016EffectON,
  title={Effect of naringin on ammonium chloride-induced hyperammonemic rats: A dose-dependent study},
  author={Ramakrishnan Arumugam and Vijayakumar Natesan and Renuka Mani},
  journal={Journal of Acute Medicine},
  year={2016},
  volume={6},
  pages={55-60}
}
Abstract Introduction In mammals, ammonia is primarily a toxin that affects the central nervous system, leading to liver damage and urea cycle disorder. Increased accumulation of ammonia results in a spectrum of effects on the central nervous system exerted through both excitatory and inhibitory neurotransmission. The aim of this investigation was to examine the protective effect of naringin on ammonium chloride (NH 4 Cl)-induced hyperammonemic rats. Materials and methods Male albino Wistar… Expand
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Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats.
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Naringin regulates glutamate-nitric oxide cGMP pathway in ammonium chloride induced neurotoxicity.
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