Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice.

@article{Dhir2005EffectON,
  title={Effect of naproxen, a non-selective cyclo-oxygenase inhibitor, on pentylenetetrazol-induced kindling in mice.},
  author={Ashish Dhir and P. S. Naidu and Shrinivas Krishnarao Kulkarni},
  journal={Clinical and experimental pharmacology & physiology},
  year={2005},
  volume={32 7},
  pages={574-84}
}
1. Epilepsy is one of the major neurological disorders of the brain, affecting approximately 0.5-1.0% of the population worldwide. Various neurotransmitter abnormalities, especially of GABA and glutamate, have been reported to play a key role in the pathophysiology of epilepsy. 2. Cyclo-oxygenase (COX) is the rate-limiting enzyme in the production of prostaglandins and, as such, is a key target for many anti-inflammatory drugs. Cyclo-oxygenase has been reported to play a significant role in… CONTINUE READING
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